What does a positive CCP test mean?
A positive result for cyclic citrullinated peptide (CCP) antibodies indicates a high likelihood of rheumatoid arthritis (RA).
A Mayo prospective clinical evaluation of the CCP antibody test showed a diagnostic sensitivity for RA of 78% with fewer than 5% false positive results in healthy controls (see Cautions)..
What does CCP test for?
A CCP antibody test is used to help diagnose rheumatoid arthritis. It’s often done along with or after a rheumatoid factor (RF) test. Rheumatoid factors are another type of autoantibody. RF tests used to be the main test to help diagnose rheumatoid arthritis.
What is considered a high anti CCP level?
An anti-CCP result up to 20 u/mL is considered negative, according to the Hospital for Special Surgery. At 20u/mL and higher, an anti-CCP test is considered positive and, with other symptoms and factors, is usually a sign of rheumatoid arthritis.
What causes elevated anti CCP?
Anti–cyclic citrullinated peptide (anti-CCP) antibody levels are characteristically elevated in rheumatoid arthritis, although they can be elevated in other rheumatologic conditions associated with inflammatory arthritis, such as systemic lupus erythematosus.